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For Your Inflammation:
The Science Behind InflaMend

InflaMend is a proprietary formula of 7 standardized extracts of herbs that reduce inflammation. InflaMend works by helping to balance enzyme levels that cause inflammatory responses in the body. Each ingredient in the InflaMend formula acts on specific enzyme pathways, helping support normal inflammation levels naturally without side effects.*

Celery Seed Extract (Apium graveolens)

Celery seed, used in Ayurvedic medicine for centuries, contains powerful phytonutrients called phthalides. New research suggest phthalides can help balance prostaglandin levels in the body, which are responsible for regulating many processes including inflammation, pain, swelling, and blood pressure. Through a unique process, these phthalides are isolated and concentrated into a standardized extract designed to optimize their health benefits.

Two capsules of InflaMend contain 150mg of celery seed extract, standardized to contain a minimum of 85% total phthalides, including 3-n-butylphthalide. This is the same dosage and potency shown in two preliminary clinical trials to significantly reduce pain, while improving mobility and quality of life, for patients with joint pain and inflammation.*^1,2

Other research shows celery seed extract also helps support healthy blood pressure and cholesterol levels because of its beneficial effect on prostaglandin levels. Researchers at the University of Chicago Medical Center identified
3-n-butylphthalide as the main factor in celery seed extract responsible for
this dual effect.*^3,4,5

Ginger Root Extract (Zingiber officinale)

Ginger is a well-known natural remedy for nausea. But it’s ginger’s effect on inflammation that is getting the most attention these days from researchers around the world.

Ginger root extract contains volatile oils and phenolic compounds such as gingerols and shogaols. Studies show ginger root, in sufficient amounts, targets pain and inflammation via two different pathways: prostaglandin enzymes and 5-lipoxygenase (5-LOX).*^6,7

According to the University of Maryland Medical Center (UMMC), a recent study of knee pain in 261 patients with osteoarthritis found those receiving the equivalent of 3 grams of fresh ginger root daily experienced less pain and required fewer pain medications with harmful side effects. The UMMC recommends 2-4 grams daily as part of an overall program to address inflammation and arthritis pain.*^8,9

Two capsules of InflaMend’s natural pain relief formula contain 300mg of ginger root extract, standardized to contain 5% gingerols. This is the equivalent of 3 grams of fresh ginger—the same dosage shown to reduce knee pain in the study above.*

InflaMend’s Proprietary Base: Balance And Function

In researching the InflaMend Proprietary Blend, RejuveNature conducted an open label consumer trial prior to launching InflaMend. From this trial, we discovered the ideal ratio of herbs that reduce inflammation and also help balance the main ingredients, celery seed extract and ginger root extract.* As a result, InflaMend’s base of 5 standardized herbal extracts helps complement the anti-inflammatory action of the main ingredients, and also virtually eliminates any stomach upset in those sensitive to ginger-based products.

Turmeric Extract (Curcuma longa): Part of the ginger family, turmeric has been shown to support proper inflammation levels by acting on both the COX-2 and 5-LOX enzymes. InflaMend contains the highest quality turmeric root extract available, standardized to contain 95% curcuminoids.*^10,11

Boswellia Extract (Boswellia serrata): Studies show that boswellia acts primarily on 5-LOX, a major inflammation pathway. InflaMend contains high-quality standardized boswellia serrata extract, containing a minimum of 60% boswellic acids.*¹²

White Willow Extract (Salix alba): One of the original natural sources of salicin used in making aspirin, white willow bark has a rich herbal history dating back nearly 2000 years. Recent research suggests white willow helps balance inflammatory enzymes via the COX-2 pathway. InflaMend contains white willow bark, standardized to contain a minimum of 15% salicin.*^13,14

Green Tea Extract (Camellia sinensis): Studies suggest green tea leaves have anti-inflammatory effects and also help protect joint structures from breakdown (also known as an anti-catabolic effect). InflaMend contains a concentrated green tea extract, standardized to contain a minimum of 50% polyphenols. Two capsules of InflaMend contain the equivalent of nearly 3 cups of brewed green tea.*^15,16

Skullcap Extract (Scutellaria baicalensis): Used for centuries in Chinese medicine, new research shows that skullcap acts on inflammation similarly to boswellia extract, via the 5-LOX enzyme pathway. InflaMend contains high-quality Chinese skullcap root, standardized to contain 30% baicalein.*^17,18

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